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With the broad range of applications of hyperthermophiles, the species has been extensively studied not only to elucidate the mechanisms of adaptation to extreme environments, but also to develop possible applications. For example, one of the species that has been most intensively studied is Pyrococcus furiosus. P. furiosus is a hyperthermophilic archaeon that has several unique features, including that it can grow anaerobically at high temperature, that its optimal growth temperature is 70° C. to 90° C., and that it utilizes Fe(III) as a reduced Fe(II) acceptor. It also produces various energy-providing polymers, such as glycogen, poly-β-1,4-glucan, and poly-β-1,4-xylan, and facilitates the production of other biomass-derived compounds, including methanol and acetate, without growing on them. These properties mean that P. furiosus is a useful microorganism for production of energy sources, chemicals and materials, and anti-freeze agents in deep-sea hydrothermal vents.
Recently, a growing number of polyhydroxyalkanoate-producing bacteria have been identified and characterized from various environments, including from psychrotolerant marine Bacteria (Hoffmann and Löffler, 1998), thermophiles (Pisera and Laub, 1993, Koyama et al., 1991, Gobler et al., 1998), and Arctic and Antarctic environments (Gobler et al., 1998, 2000, Thieme et al., 2000), but there have been no reports on the identification of any species of hypertherm
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A significant proportion of the global disability burden is attributable to brain disorders, including dementias, which are characterized by the progressive loss of cognitive and functional abilities. Although several biological and environmental risk factors have been linked to dementia, the interaction between them is complex, and it is not yet possible to predict which risk factors and which combinations of risk factors will influence disease progression.
Based on a mathematical model of Alzheimer’s disease, as well as on evidence of the slow cognitive decline that occurs in the prodromal stages of dementia, the authors have simulated a model of disease progression to reduce the spread of dementia to a population of 100,000, including the risk factors reported in the literature.
The simulation of the model shows that all the risk factors studied, when considered individually, are insufficient to promote the same percentage of the population reaching dementia. However, there are synergistic combinations of risk factors that promote the same percentages of dementia in the same years. For example, the population having two risk factors in combination present the lowest age of onset, as well as the highest percentage reaching dementia at the age of 85.
The quantification of risk factors plays a fundamental role in identifying groups at risk and in determining the timing and the intensity of interventions in order to reduce the impact of dementia.
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